Sarecycline hydrochloride

SKU: orb2901501

Description

Sarecycline hydrochloride is an orally active narrow-spectrum tetracycline derivative antibiotic. Sarecycline hydrochloridehas anti-inflammatory activity. Sarecycline hydrochloride inhibits the activity of Gram-positive bacteria and several types of keratobacterium acnes. Sarecycline hydrochloride interferes with tRNA accommodation and tethers mRNA to the 70S ribosome. Sarecycline hydrochloride can be used to study moderate to severe acne.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 1035979-44-2
• MW: 523.96
• Purity: >98% (HPLC)
• Formula: C₂₄H₃₀ClN₃O₈
• SMILES: O[C@]12[C@]([C@H](N(C)C)C(O)=C(C(N)=O)C1=O)(C[C@]3(C(=C2O)C(=O)C=4C(C3)=C(CN(OC)C)C=CC4O)[H])[H].Cl
• Target: Antibacterial
• Solubility: In Vitro: DMSO : 100 mg/mL (190.85 mM; Ultrasonic )

Bioactivity

• In Vivo:
  Animal model: Female SD-1 mice (A murine neutropenic thigh wound infection model). Dosage: 0.33, 1, 3, or 9 mg/kg. Administration: Intravenously. Result: Achieved a 2-log10 reduction in the bacterial burden in the thigh at a dose comparable to that of doxycycline, with ED50s of 8.23 and 8.32 mg/kg, respectively. Animal model: Carrageenan-induced footpad edema male Sprague Dawley rats model. Dosage: 1 mg/kg, 5 mg/kg, 10 mg/kg, 25 mg/kg, 50 mg/kg, 75 mg/kg, 100 mg/kg, 150 mg/kg. Administration: Intraperitoneal injection (i.p.); Single dose. Before a subplantar injection of sterile 1 mg/0.1 mL carrageenan solution in the right hind paw. Result: Reduced inflammation to 55.7% and 53.1%, respectively, at doses of 75 mg/kg and 100 mg/kg compared to baseline.
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Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

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Gene Symbol

Antibacterial