Salvigenin

SKU: orb1297628

Description

Salvigenin

Research Area

Cell Biology, Metabolism Research, Neuroscience, Signal Transduction

Key Properties

• CAS Number: 19103-54-9
• MW: 328.32
• Purity: 99.17%
• Formula: C₁₈H₁₆O₆
• SMILES: COc1ccc(cc1)-c1cc(=O)c2c(O)c(OC)c(OC)cc2o1
• Target: ROS Kinase,MAO,Apoptosis,Autophagy
• Solubility: DMSO:4.4 mg/mL (13.4 mM)

Bioactivity

• In Vitro:
  Co-administration of flavonoids(eupatorin and salvigenin) with doxorubicin induced apoptosis via the mitochondrial pathway as mitochondrial membrane potential and ROS production were changed. Annexin/PI analysis demonstrated that apoptosis frequency was increased with the combination treatments in colon cancer cells. Finally, the combination of these flavonoids with doxorubicin increased the Bax/Bcl-2 ratio, caspase-3 expression and PARP cleavage.
• Cell Research:
  Upon establishing a non-effective dose of doxorubicin, and effective doses of eupatorin (100μM) and salvigenin (150μM) via MTT, morphological features of apoptosis were distinguished using DAPI staining and cell cycle blockage in the sub-G1 phase. Apoptosis was determined by annexin/ PI and western blotting. ROS levels and MMP were measured to show any role of mitochondria in apoptosis.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

antioxidant, Autophagy, Apoptosis, Inhibitor, hMAO-A, inhibit, immunomodulatory, neuroprotective, Salvigenin, ROS Kinase, ROSKinase

Compound Identifiers

PubChem CID

161271