Salvigenin

SKU: orb1220307

Description

Salvigenin is a potent hMAO-A inhibitor has neuroprotective antitumor and immunomodulatory effects.

Key Properties

• CAS Number: 19103-54-9
• MW: 328.32
• Purity: >98% (HPLC)
• Formula: C₁₈H₁₆O₆
• SMILES: COc1ccc(-c2cc(=O)c3c(O)c(OC)c(OC)cc3o2)cc1
• Target: MAO
• Solubility: In Vitro: DMSO : 20 mg/mL (60.92 mM)

Bioactivity

• In Vivo:
  Salvigenin (0-9.68 μg/mouse/day; i.p.; 4 or 12 days) shows antitumor and immunomodulatory effects on tumor bearing mice. Animal model: MCF-7 cell bearing inbred female Balb/c mice, aged from six to eight weeks. Dosage: 3.65, 5.85 and 9.68 μg/mouse/day for four days or 12 days. Administration: Intraperitoneal injection. Result: Showed a significant increase in DTH response in a dose-dependent manner. Significantly decreased the rate of tumor growth, increased lymphocyte proliferation index, increased the level of IFN-γ and decreased IL-4 production. Exhibited a significant decrease of the splenic CD4+CD25+Foxp3+ T lymphocytes.
• In Vitro:
  Salvigenin (0-100 μM, 3 h) protects SH-SY5Y cells against H2O2-induced cell death. Salvigenin (0-100 μM, 2 h) significantly reduces ROS generation, increases the glutathione level, declines the extent of cell apoptosis and increases autophagy in H2O2-exposed SH-SY5Y cells. Cell Viability Assay Cell line: SY5Y cells exposed to H2O2 (300 μM). Concentration: 10, 25, 50, and 100 μM. Incubation time: 3 h. Result: Protected SH-SY5Y cells (best in 25 and 50 μM) against H2O2-induced cell death. Apoptosis Analysis Cell line: SY5Y cells exposed to H2O2 (300 μM). Concentration: 10, 25, 50, and 100 μM. Incubation time: 2 h. Result: Significantly declined the extent of cell apoptosis induced by H2O2. Western blot analysis. Cell line: SY5Y cells exposed to H2O2 (300 μM). Concentration: 10, 25, 50, and 100 μM. Incubation time: 2 h. Result: Reduced cleaved caspase-3 and Bax/Bcl-2 ratio. Reduced caspase-12 and calpain levels. Reduced the level of Atg7, Atg12, and LC3-II/ LC3-I.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

MAO