S65487

SKU: orb1693349

Description

S65487 (VOB560) is a potent and selective Bcl-2 inhibitor active against wild-type and mutant forms (e.g., G101V, D103Y). Its high selectivity over MCL-1, BFL-1, and BCL-XL underpins its utility in apoptosis research, demonstrating robust anticancer activity in both cellular assays and in vivo preclinical models.

Research Area

Cell Biology

Key Properties

• CAS Number: 1644600-79-2
• MW: 717.26
• Purity: 99.03% (May vary between batches)
• Formula: C₄₁H₄₁ClN₆O₄
• SMILES: N(C(=O)C=1C=C(N(C)C1C)C2=C(C(=O)N3[C@H](CN4CCOCC4)CC=5C(C3)=CC=CC5)C=CC(Cl)=C2)(C=6C=C(C#N)N(C)C6C)C7=CC=C(O)C=C7
• Target: Apoptosis,Others,Bcl-2 Family
• Solubility: DMSO:160 mg/mL (223.07 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:5 mg/mL (6.97 mM)

Bioactivity

• In Vivo:
  S65487 effectively induces complete regression in BCL-2-dependent RS4;11 tumors through a single intravenous (IV) dose and demonstrates consistent, strong tumor regression in mouse and rat xenograft models of lymphoid malignancies at tolerable doses with weekly IV administrations when combined with MCL-1-specific inhibitor S64315/MIK665.
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• In Vitro:
  S65487 effectively induces apoptosis and inhibits proliferation in a panel of hematologic cancer cell lines by binding to the BH3 hydrophobic groove of the BCL-2 protein, with a half-maximal inhibitory concentration (IC50) in the low nanomolar (nM) range.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

S 65487, S65487, S-65487, VOB 560, VOB560

Compound Identifiers

PubChem CID

112500313