S55746

SKU: orb1309133

Description

S55746 (BLC201) is a potent and selective small molecule BCL-2 inhibitor with a Ki of 1.3 nM and a Kd of 3.9 nM. It is a valuable research tool for studying apoptosis mechanisms and has demonstrated anti-tumor activity in both cellular assays and in vivo models of hematological cancers.

Research Area

Cell Biology

Key Properties

• CAS Number: 1448584-12-0
• MW: 710.82
• Purity: 99.91% (May vary between batches)
• Formula: C₄₃H₄₂N₄O₆
• SMILES: Oc1ccc(cc1)N(C(=O)c1cc(-c2cc3OCOc3cc2C(=O)N2Cc3ccccc3C[C@H]2CN2CCOCC2)n2CCCCc12)c1ccccc1
• Target: Bcl-2 Family
• Solubility: DMSO:44 mg/mL (61.9 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (2.81 mM)

Bioactivity

• Target IC50:
  Bcl-2:3.9 nM (kd)|Bcl-2:1.3 nM (Ki)|Bcl-xL:520 nM (Ki)|Bcl-xL:186 nM (Kd)
• In Vivo:
  S55746 is a potent and well-tolerated oral BCL-2 inhibitor, effective even at doses up to 300 mg/kg. At doses of 20-100 mg/kg (p.o.), S55746 inhibits xenograft growth in RS4 .
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• In Vitro:
  S55746 selectively causes apoptosis through BCL-2 inhibition in a BAX/BAK-dependent manner. S55746 (0-1 μM) effectively and selectively induces cell death .
  Read more...

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Bcl-2, BCL 201, Bcl-xL, BCL201, BCL-201, Bcl-2 Family, BLC 201, BLC201, BLC-201, inhibit, Inhibitor, S55746, S-55746, S 55746

Compound Identifiers

PubChem CID

71654876