S-(+)-Ketoprofen

SKU: orb1310245

Description

S-(+)-Ketoprofen is the active enantiomer of the NSAID ketoprofen, functioning as a cyclo-oxygenase (COX) inhibitor to block prostaglandin synthesis and provide both peripheral and central analgesic effects. It is widely used in pharmacological research to study inflammation and pain mechanisms in both in vitro enzyme assays and in vivo animal models of nociception and edema.

Research Area

Immunology & Inflammation, Neuroscience

Key Properties

• CAS Number: 22161-81-5
• MW: 254.28
• Purity: >99.99% (May vary between batches)
• Formula: C₁₆H₁₄O₃
• SMILES: C[C@H](C(O)=O)c1cccc(c1)C(=O)c1ccccc1
• Target: COX
• Solubility: DMSO:125 mg/mL (491.58 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (15.73 mM)

Bioactivity

• Target IC50:
  COX-1:1.9 nM|COX-2:27 nM

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

(S)-(+)-Ketoprofen, (S)-Ketoprofen, COX, COX-2, COX-1, Dexketoprofen, Cyclooxygenase, Ketoprofen, inhibit, Inhibitor, RP 19583, RP19583, RP-19583, S-Ketoprofen, S (+) Ketoprofen, S(+)Ketoprofen

Compound Identifiers

PubChem CID

667550