RU-301

SKU: orb1220415

Description

RU-301 is a novel pan-tam inhibitor.

Key Properties

• CAS Number: 1110873-99-8
• MW: 480.46
• Purity: >98% (HPLC)
• Formula: C₂₁H₁₉F₃N₄O₄S
• SMILES: Cc1cc(CSc2ccccc2C(=O)NCCNc2ccc(C(F)(F)F)cc2[N+](=O)[O-])on1
• Target: TAM Receptor
• Solubility: In Vitro: DMSO : 100 mg/mL (208.13 mM)

Bioactivity

• In Vivo:
  Animal model: NOD/SCIDγ mice (4-6 week; lung cancer xenograft model). Dosage: 100, 300 mg/kg. Administration: Intraperitoneal injection; single daily for 4 days. Result: Significantly decreased tumor volume while body weights were not significantly different. Showed no notable toxicity but displayed good bioavailability with a t1/2 life of ~7-8 hours. Animal model: WT or Mertk / male mice (fed NASH diet for 12 weeks). Dosage: 300 mg/kg. Administration: Intraperitoneal injection; 3 times a week for 4 weeks. Result: Reduced liver fibrosis as indicated by decreases in liver picrosirius red staining and collagen gene expression.
  Read more...
• In Vitro:
  Cell Viability Assay Cell line: H1299, MDA-MB-231 cells. Concentration: 10 μM (for H1299); 2.5, 5 μM (for MDA-MB-231) Incubation time: 30 min (pre-incubate). Result: Suppressed Gas6-inducible native phosphorylation of native Axl. Partially blocked Gas6-induced activation of Akt and Erk in H1299 or MDA-MB-231 at 5 μM. Inhibited the Gas6-induced phosphorylation of not only native Axl but also native Tyro3 and MerTK in H1299 at 10 μM. Cell Migration Assay Cell line: H1299, MDA-MB-231 cells. Concentration: 10 μM. Incubation time: 24 h. Result: Strongly suppressed Gas6-inducible motility of H1299 lung cancer cell line. Cell Viability Assay Cell line: H1299 cells. Concentration: 10 μM. Incubation time: 14 days. Result: Suppressed clonogenic growth of H1299 cells when cultured in the presence of Gas6.
  Read more...

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

TAM Receptor