RRX-001

SKU: orb1299853

Description

RRX-001

Research Area

Cell Biology, Infectious Disease & Virology, Metabolism Research

Key Properties

• CAS Number: 925206-65-1
• MW: 268.02
• Purity: 99.91%
• Formula: C₅H₆BrN₃O₅
• SMILES: [O-][N+](=O)C1(CN(C1)C(=O)CBr)[N+]([O-])=O
• Target: Apoptosis,Parasite,Dehydrogenase
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:5 mg/mL (18.66 mM);DMSO:250 mg/mL (932.77 mM)

Bioactivity

• In Vitro:
  RRx-001 inhibited the growth of colon cancer cells (HCT 116) and decreased levels of the DNA methyltransferases DNMT1 and DNMT3a in a time and dose-dependent manner. Treatment of HCT 116 cells with 0.5 μM RRx-001 for 24 h significantly increased transcripts of interferon (IFN)-responsive genes and this induction was sustained for up to 4 weeks after transient exposure to RRx-001. RRx-001 increased secretion of type I and III IFNs by HCT 116 cells, and these IFNs were confirmed to be bioactive. Transcription of endogenous retrovirus ERV-Fc2 and LTRs from the ERV-L family (MLT2B4 and MLT1C49) was induced by RRx-001.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Inhibitor, G6PD, Parasite, inhibit, Apoptosis, RRX 001, RRX001, RRx-001, RRX-001

Compound Identifiers

PubChem CID

15950826