RRX-001

SKU: orb1223635

Description

RRX-001 (RRX001) is a novel NO and hypoxia mediated anticancer agent with with epigenetic and immunologic activity; targets CD133 + /CD44 + cancer stem cells from colon cancer cell-lines, HT-29, Caco-2, and HCT116, and inhibits Wnt pathway signalling with downregulation of c-Myc; inhibits HCT 116 and decreases levels of the DNA methyltransferases DNMT1 and DNMT3a in a time and dose-dependent manner; RRX-001 (RRX001) is a chemosensitizer in multiple tumor types and disease states including malaria, hemorrhagic shock and sickle cell anemia.Lung Cancer Phase 2 Clinical.

Key Properties

• CAS Number: 925206-65-1
• MW: 268.023
• Purity: >98% (HPLC)
• Formula: C₅H₆BrN₃O₅
• SMILES: O=[N+](C1([N+]([O-])=O)CN(C(CBr)=O)C1)[O-]
• Target: Other Targets
• Solubility: DMSO : ≥ 100 mg/mL 373.11 mM

Bioactivity

• In Vivo:
  Animal model: CB-17 SCID-mice were subcutaneously inoculated with 5.0 × 106 MM. 1S cells in 100 μL of serum-free RPMI 1640 medium. Dosage: 5 mg/kg or 10 mg/kg. Administration: I. V. , thrice-weekly for 24 days. Result: Blocked MM tumor growth and enhances survival. Treatment was well tolerated, suggested by no apparent weight loss. Animal model: Female BALB/c nude mice (19.2 ± 1.7 g) based on A549 lung cancer model. Dosage: 10 mg/kg. Administration: IP, twice a week and once a day. Result: Resulted in the most significant tumor growth retardation. Reduction of resident macrophages in tumor-bearing mice attenuates the antitumor activity of RRx-001.
• In Vitro:
  Cell Viability Assay Cell line: Human MM-cell lines (MM.1S, RPMI-8226, H929, ARP1, KMS-11, OPM2, LR5, ANBL6.WT), along with drug resistant cell lines such as (MM.1R, Dox40, LR5, ANBL6.BR, RPMI-8226). Concentration: 0-5 μM. Incubation time: 24 hours. Result: Induced a dose-dependent significant (p < 0.05) decrease in viability of all cell lines.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

RRX001 | RRX 001

Quick Database Links

Gene Symbol

Other Targets