Rosuvastatin calcium

SKU: orb1226214

Description

A potent, competitive inhibitor of HMG-CoA reductase (HMGCR) with IC50 of 11 nM; potently inhibits cholesterol biosynthesis (IC50=1.12 nM) in rat isolated hepatocytes, 100 times more potent than pravastatin; also exerts important anti-inflammatory effects via inhibition of endothelial cell adhesion molecule expression.Dyslipidemia Approved(In Vivo):Rosuvastatin Calcium (10 mg/kg, intraperitoneal) prolonges QTc in conscious and unrestraines guinea pigs from 201±1 to 210±2 ms.Rosuvastatin (20 mg/kg/day, for 2 weeks) significantly reduces very low-density lipoproteins Calcium (VLDL) in diabetes mellitus rats induced by Streptozocin.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 147098-20-2
• MW: 500.57
• Purity: >98% (HPLC)
• Formula: C₂₂H₂₇Ca₀.5FN₃O₆S
• SMILES: CC(C1=NC(=NC(=C1/C=C/[C@@H](O)C[C@@H](O)CC(=O)[O-])C2=CC=C(C=C2)F)N(S(=O)(=O)C)C)C.CC(C1=NC(=NC(=C1/C=C/[C@@H](O)C[C@@H](O)CC(=O)[O-])C2=CC=C(C=C2)F)N(S(=O)(=O)C)C)C.[Ca+2]
• Target: HMGCR
• Solubility: 10 mM in DMSO

Bioactivity

• In Vivo:
  Rosuvastatin Calcium (10 mg/kg, intraperitoneal) prolonges QTc in conscious and unrestraines guinea pigs from 201±1 to 210±2 ms. Rosuvastatin (20 mg/kg/day, for 2 weeks) significantly reduces very low-density lipoproteins Calcium (VLDL) in diabetes mellitus rats induced by Streptozocin.
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Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

ZD-4522 calcium

Quick Database Links

Gene Symbol

HMGCR