Rosuvastatin calcium

SKU: orb1308393

Description

Rosuvastatin calcium is a potent, selective, and competitive inhibitor of HMG-CoA reductase, exhibiting significant antilipidemic activity. It is widely used in research to study cholesterol biosynthesis and atherosclerosis in both in vitro enzymatic assays and in vivo animal models.

Research Area

Cell Biology, Infectious Disease & Virology, Metabolism Research, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 147098-20-2
• MW: 1001.14
• Purity: 98.21% (May vary between batches)
• Formula: 2(C₂₂H₂₇FN₃O₆S)Ca
• SMILES: [Ca++].CC(C)C1=C(\C=C\[C@@H](O)C[C@@H](O)CC([O-])=O)C(=NC(=N1)N(C)S(C)(=O)=O)C1=CC=C(F)C=C1.CC(C)C1=C(\C=C\[C@@H](O)C[C@@H](O)CC([O-])=O)C(=NC(=N1)N(C)S(C)(=O)=O)C1=CC=C(F)C=C1
• Target: HMG-CoA Reductase,Antibacterial,Potassium Channel,Autophagy
• Solubility: DMSO:123 mg/mL (122.86 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (4 mM)

Bioactivity

• Target IC50:
  HMG-CoA:11 nM
• In Vivo:
  In isolated rat hepatocytes (IC50=1.12 nM), Rosuvastatin acts as a high-affinity substrate for OATP-C, inhibiting cholesterol synthesis. Additionally, in endothelial cells, Rosuvastatin suppresses the expression and protein levels of ICAM-1, MCP-1, IL-8, IL-6, and COX-2 mRNA by inhibiting the c-Jun N-terminal kinase and nuclear factor-kB.
• In Vitro:
  In streptozotocin-induced diabetic rats, daily administration of Rosuvastatin (20 mg/kg) significantly reduces the content of very low-density lipoprotein (VLDL) within the body. Similarly, in male beagles with normal cholesterol levels, Rosuvastatin (3 mg/kg) effectively lowers the concentration of cholesterol in the plasma.

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

low-density, lipoprotein, HMGCoA Reductase, HMGCoAReductase, HMG-CoA reductase, HMGCR, Hsp70, action, APDs, Autophagy, durations, cholesterol, cardiac, Rosuvastatin, Rosuvastatin calcium, Rosuvastatin hemicalcium, repolarization, ZD-4522, ZD 4522, ZD 4522 Calcium, QTc, Potassium Channel, PotassiumChannel, potential, triglycerides

Compound Identifiers

PubChem CID

5282455