RORγt inverse agonist 13

SKU: orb1297973

Description

Compound 3i is a potent and selective RORγt inverse agonist with an IC50 of 63.8 nM, demonstrating oral activity and favorable drug-like properties. It is a valuable research tool for investigating Th17 cell biology and autoimmune diseases in both cellular and animal models.

Research Area

Metabolism Research

Key Properties

• CAS Number: 2170477-75-3
• MW: 513.29
• Purity: 99.04% (May vary between batches)
• Formula: C₂₃H₁₇Cl₂F₃N₂O₄
• SMILES: OC(=O)Cc1ccc(CNC(=O)Nc2cc(Cl)c(c(Cl)c2)-c2ccccc2OC(F)(F)F)cc1
• Target: ROR
• Solubility: 10% DMSO+90% Corn Oil:1 mg/mL (1.95 mM);DMSO:10 mg/mL (19.48 mM)

Bioactivity

• Target IC50:
  RORγ:63.8 nM
• In Vivo:
  RORγt inverse agonist 13 (Compound 3i, 25 mg/kg, orally, twice daily) demonstrates an excellent in vivo PK profile and good efficacy in an IMQ-induced psoriasis mouse model.
• In Vitro:
  RORγt inverse agonist 13 (Compound 3i) demonstrates 76% inhibition at 0.3 μM in the Th17 cell differentiation assay.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

inhibit, Inhibitor, ROR, RORγt inverse agonist13, RORγt inverse agonist-13, RORγt, RORγt inverse agonist 13, RORgammat inverse agonist 13, RORrt inverse agonist 13, RAR-related orphan receptor

Compound Identifiers

PubChem CID

138583953