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Roflumilast
Catalog Number: orb1310022
| Catalog Number | orb1310022 |
|---|---|
| Category | Small Molecules |
| Description | Roflumilast |
| CAS Number | 162401-32-3 |
| Purity | 99.76% |
| MW | 403.21 |
| SMILES | O(CC1CC1)C2=C(OC(F)F)C=CC(C(NC=3C(Cl)=CN=CC3Cl)=O)=C2 |
| Formula | C17H14Cl2F2N2O3 |
| Biological Activity | Roflumilast (APTA 2217) is an orally available, long-acting inhibitor of phosphodiesterase (PDE) type 4 (PDE4), with anti-inflammatory and potential antineoplastic activities. Upon administration, roflumilast and its active metabolite roflumilast N-oxide selectively and competitively bind to and inhibit PDE4, which leads to an increase of both intracellular levels of cyclic-3', 5'-adenosine monophosphate (cAMP) and cAMP-mediated signaling. |
| Storage | -20°C |
| Note | For research use only |
| Expiration Date | 12 months from date of receipt. |
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Roflumilast [orb180792]
[162401-32-3]
403.21
C17H14Cl2F2N2O3
1 ml x 10 mm (in DMSO), 1 g, 100 mg, 250 mg Roflumilast N-oxide [orb1302839]
99.65%
292135-78-5
419.21
C17H14Cl2F2N2O4
1 ml x 10 mm (in DMSO), 10 mg, 50 mg, 100 mg, 2 mg, 5 mg, 25 mg, 1 mg, 500 mg
