PDE4B-IN-6

SKU: orb3172888

Description

PDE4B-IN-6 (Compound 4i) is a potent and highly selective inhibitor of phosphodiesterase 4B (PDE4B) with an IC50 of 7.42 nM. As a roflumilast analogue, it exhibits significantly higher selectivity for PDE4B over PDE4A (IC50 = 1540 nM, ~195-fold) and PDE4C (IC50 = 1260 nM, ~169-fold). PDE4B-IN-6 exerts anti-inflammatory effects by elevating intracellular cAMP levels and suppressing the expression of the pro-inflammatory cytokine TNF-α. Additionally, it demonstrates good antioxidant properties and low cytotoxicity, making it suitable for research on chronic obstructive pulmonary disease (COPD) and related inflammatory conditions.

Key Properties

• MW: 466.43
• Purity: 99.20% (May vary between batches)
• Formula: C₂₂H₂₄F₂N₂O₇
• SMILES: FC(F)OC1=CC=C(C(NNC(C2=CC(OC)=C(OC)C(OC)=C2)=O)=O)C=C1OCC3CC3
• Target: PDE

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

PDE