Robinetin

SKU: orb1940112

Description

Robinetin has antioxidant and antiradical activities, inhibits EYPC membrane lipid peroxidation and HbA glycosylation with high efficiency.(In Vitro):Robinetin inhibits the DNA synthesis in Proteus vulgaris, and the RNA synthesis in S. aureus. Robinetin exhibits photo-induced excited-state intramolecular proton transfer resulting in ‘two color’ (in ‘blue-violet’ and ‘yellow-green’ regions) fluorescence characteristic of flavonols, the relative contributions between the two colors being strongly modulated by the local environment of the fluorophore. Robinetin (0.1-10 μM; 1 h) inhibits HIV integrase cleavage and integration in a dose-dependent manner.(In Vivo):Pretreatment with 0.5, 12.5 or 25 mumol robinetin resulted in elevated induction of epidermal ODC by TPA at 6 h after TPA. However, treatment with 50 or 100 mumol robinetin diminished ODC induction at 6 h after TPA. Anti-mutagenicity was determined in the Salmonella typhimurium assay, Robinetin caused an 87% inhibition of mutagenicity by 2-aminoanthracene.

Key Properties

• CAS Number: 490-31-3
• MW: 302.238
• Purity: >98% (HPLC)
• Formula: C₁₅H₁₀O₇
• SMILES: Oc1ccc2c(c1)oc(-c1cc(O)c(O)c(O)c1)c(O)c2=O
• Target: Antifection
• Solubility: In Vitro: DMSO : 120 mg/mL (397.04 mM)

Bioactivity

• In Vitro:
  Robinetin (0.1-10 μM; 1 h) inhibits HIV integrase cleavage and integration in a dose-dependent manner. Robinetin inhibits the DNA synthesis in Proteus vulgaris, and the RNA synthesis in S. aureus. Robinetin (100-200 or 25 μM; 1 or 72 h) inhibitsegg yolk phosphatidylcholine (EYPC) membrane lipid peroxidation and hemoglobin A (HbA) glycosylation with high efficiency. Robinetin exhibits photo-induced excited-state intramolecular proton transfer resulting in ‘two color’ (in ‘blue-violet’ and ‘yellow-green’ regions) fluorescence characteristic of flavonols, the relative contributions between the two colors being strongly modulated by the local environment of the fluorophore.
  Read more...

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

3,3',4',5',7-Pentahydroxyflavone

Quick Database Links

Gene Symbol

Antifection