Robinetin

SKU: orb1297217

Description

Robinetin

Research Area

Infectious Disease & Virology, Protein Biochemistry

Key Properties

• CAS Number: 490-31-3
• MW: 302.24
• Purity: 99.61% (May vary between batches)
• Formula: C₁₅H₁₀O₇
• SMILES: Oc1ccc2c(c1)oc(-c1cc(O)c(O)c(O)c1)c(O)c2=O
• Target: Antibacterial,Antifungal,Anti-infection,HIV Protease
• Solubility: DMSO:100 mg/mL (330.86 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (13.23 mM)

Bioactivity

• In Vivo:
  Pretreatment with 0.5, 12.5 or 25 mumol robinetin resulted in elevated induction of epidermal ODC by TPA at 6 h after TPA. However, treatment with 50 or 100 mumol robinetin diminished ODC induction at 6 h after TPA. Anti-mutagenicity was determined in the Salmonella typhimurium assay, Robinetin caused an 87% inhibition of mutagenicity by 2-aminoanthracene
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• In Vitro:
  Robinetin inhibits the DNA synthesis in Proteus vulgaris, and the RNA synthesis in S. aureus. Robinetin exhibits photo-induced excited-state intramolecular proton transfer resulting in ‘two color’ (in ‘blue-violet’ and ‘yellow-green’ regions) fluorescence characteristic of flavonols, the relative contributions between the two colors being strongly modulated by the local environment of the fluorophore. Robinetin (0.1-10 μM; 1 h) inhibits HIV integrase cleavage and integration in a dose-dependent manner.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

peroxidation, Robinetin, protein, antiviral, antifungal, antibacterial, antioxidant, antimutagenesis, Anti-infection, Antiinfection, Bacterial, 3,3',4',5',7-Pentahydroxyflavone, HIV Protease, HIV Integrase, HIV, HIVProtease, Fungal, glycosylation, flavonoid, Inhibitor, inhibit, lipid

Compound Identifiers

PubChem CID

5281692