RICTOR Antibody (C-term)

SKU: orb37672

Description

Rabbit polyclonal antibody to RICTOR (Rapamycin insensitive companion of mTOR antibody) is also known as AVO3, PIA. It belongs to the pianissimo family. The Rictor-FRAP complex plays a role in PKC alpha phosphorylation, directly phosphorylates Akt/PKB on Ser473 in vitro and facilitates Thr308 phosphorylation by PDK1and it has also function as a drug target in tumors that have lost expression of PTEN, a tumor suppressor that opposes activation of Akt/PKB.

Research Area

Cell Biology, Signal Transduction

Images & Validation

• Tested Applications: IHC-P, WB
• Dilution Range: WB: 1:1000, IHC-P: 1:10-50
• Reactivity: Human, Mouse

Key Properties

• Antibody Type: Primary Antibody
• Host: Rabbit
• Clonality: Polyclonal
• Isotype: Rabbit IgG
• Clone No.: RB14641
• Immunogen: Synthetic Peptide
• Target: RICTOR
• Molecular Weight: 192218
• Conjugation: Unconjugated

Storage & Handling

• Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
• Form/Appearance: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Anti-KIAA1999 antibody

RICTOR Antibody (C-term) western blot analysis in mouse bladder tissue lysates (35 ug/lane). This demonstrates the RICTOR antibody detected the RICTOR protein (arrow).

RICTOR Antibody (C-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human kidney tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of RICTOR Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.

Quick Database Links

Gene Symbol

RICTOR

UniProt

Q6R327

RefSeq (Protein):NP_689969.2