Riboflavin

SKU: orb1310153

Description

Riboflavin (Vitamin B2) is an essential micronutrient and endogenous metabolite that serves as the precursor for the coenzymes FMN and FAD. It is critical in cellular energy production, redox metabolism, and antibody synthesis, making it a key compound for in vitro biochemical assays and in vivo studies of nutrition, metabolism, and mitochondrial function.

Research Area

Infectious Disease & Virology, Metabolism Research, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 83-88-5
• MW: 376.36
• Purity: 97.73% (May vary between batches)
• Formula: C₁₇H₂₀N₄O₆
• SMILES: CC1=C(C)C=C2N(CC(O)C(O)C(O)CO)C3=NC(=O)NC(=O)C3=NC2=C1
• Target: Endogenous Metabolite,Antibacterial
• Solubility: DMSO:3.77 mg/mL (10.02 mM);H2O:Insoluble

Bioactivity

• In Vivo:
  METHODS: To investigate the effects on LPS-induced shock in mice, Riboflavin (1-10 mg/kg) was injected intraperitoneally into BALB/c mice, followed by LPS. RESULTS: High doses of Riboflavin reduced LPS-induced mortality by increasing HSP25 expression.
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• In Vitro:
  METHODS: Rat pancreatic islet cells were treated with Riboflavin (10 µM) for 3 days and cell viability was measured by Trypan blue assay. RESULTS: Riboflavin supplementation had no effect on the viability of HEK293T17 cells. METHODS: Rainbow trout gonadal cells RTG-2 were treated with Riboflavin (10 µM) for 24 h. Islet number was measured by DTZ staining. RESULTS: Riboflavin-treated islets had modest but statistically significantly higher recovery rates of 75.2±1.6% and 69.3±2.0%, respectively.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Riboflavin, VB2, Vitamin B2, Vitamin B-2, Vitamin B 2, E101, E-101, Endogenous Metabolite, E 101, inhibit, Inhibitor, EndogenousMetabolite

Compound Identifiers

PubChem CID

1072