Riboflavin

SKU: orb1223900

Description

Nutritional factor found in milk, eggs, malted barley, liver, kidney, heart, and leafy vegetables. The richest natural source is yeast. It occurs in the free form only in the retina of the eye, in whey, and in urine; its principal forms in tissues and cells are as flavin mononucleotide and flavin-adenine dinucleotide.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 83-88-5
• MW: 376.37
• Purity: >98% (HPLC)
• Formula: C₁₇H₂₀N₄O₆
• SMILES: CC1=CC2=C(C=C1C)N(C3=NC(=O)NC(=O)C3=N2)C[C@@H]([C@@H]([C@@H](CO)O)O)O
• Target: Vitamin
• Solubility: DMSO: 0.1 mg/mL (0.26 mM); Water; Ethanol: insoluble

Bioactivity

• In Vivo:
  Animal model: Swiss albino mice. Dosage: 10 mg/kg. Administration: Oral gavage (p.o.), daily. Result: Increased the growth rate of pregnant and newbron mice. Increased the percent conception and average litter size of pregnant mices. Improved the percent zinc absorption in male mices. Increased the levels of zinc and iron in organs in male and female mices. Increased the percent hemoglobin and the blood zinc value of female mices. Animal model: Female Wistar rats. Dosage: 1-600 mg/kg. Administration: Oral gavage (p.o.), one time. Result: Reduced flinching behavior during phase 2 in formalin-injected mice by doses of 1-50 mg/kg. Produced a significant antihyperalgesic effect in carrageenan-injected mice by doses of 6.25-150 mg/kg. Reduced carrageenan-induced edema by doses of 50-150 mg/kg.
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• In Vitro:
  Cell Viability Assay Cell line: HL60 cells. Concentration: 5-10 μM. Incubation time: 24 h. Result: Didn't affect cell viability with no UV irradiation. Western blot analysis. Cell line: HL60 cells. Concentration: 5-50 μM. Incubation time: 24 h. Result: Increased the ratio Bax/Bcl2 and decreased the level of inhibitory apoptosis protein type 1 (IAP1). Caused overexpression of Fas and FasL. Decreased the expression of TNFR1 and TRADD at the concentration of 10-50 μM. Inhibited the cell survival relevant kinases phospho-JNK, phospho-MEK, phospho-ERK. Increased the expression of p21 and decreased the expression of PCNA, STATs 1 and STATs 2.
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Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Riboflavin, Vitamin B2, Vitamin G | Lactoflavin

Quick Database Links

Gene Symbol

Vitamin