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RI-2

SKU: orb1223316

Description

RI-2 is an optimized RAD51 inhibitor with an IC50 of 44.17 μM in the standard DNA binding assay; specifically inhibits HR(Homologous recombination) repair in human cells.

Images & Validation

Key Properties

CAS Number1417162-36-7
MW433.28
Purity>98% (HPLC)
FormulaC21H18Cl2N2O4
SMILESCOc1ccc(cc1)C1=C(N2CCOCC2)C(=O)N(C1=O)c1cc(Cl)c(Cl)cc1
TargetPAK
SolubilityDMSO : 15.5 mg/mL 35.77 mM;

Bioactivity

In Vitro
RI-2 (7a) is a reversible RAD51 inhibitor, with an IC50 of 44.17 μM. RI-2 specifically inhibits homologous recombination repair in human cells. RI-2 (150 μM) induces a significant sensitization of cells.

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

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    433.28

    C21H18Cl2N2O4

    1 mg, 2 mg, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg, 1 ml x 10 mM (in DMSO)
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Protocol Information

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200 mg
500 mg
2 mg
$ 170.00
5 mg
$ 270.00
10 mg
$ 470.00
25 mg
$ 720.00
50 mg
$ 1,050.00
100 mg
$ 1,480.00