RI-1

SKU: orb1225089

Description

RI-1 is a RAD51 inhibitor with IC50 ranging from 5 to 30μM.

Key Properties

• CAS Number: 415713-60-9
• MW: 361.61
• Purity: >98% (HPLC)
• Formula: C₁₄H₁₁Cl₃N₂O₃
• SMILES: ClC1=C(N2CCOCC2)C(=O)N(C1=O)C1=CC(Cl)=C(Cl)C=C1
• Target: DNA/RNA Synthesis
• Solubility: DMSO: 50 mg/mL (138.27 mM)

Bioactivity

• In Vivo:
  RI-1 (50 mg/kg; i.p. every 3 d for 30 d) significantly reduces triple negative breast cancer (TNBC) tumor growth in mice. Animal model: Female BALB/c nude mice (6 weeks) bearing TNBC tumor. Dosage: 50 mg/kg. Administration: i.p. every 3 days for 30 days. Result: Resulted in significant inhibition of tumor growth.
• In Vitro:
  RI-1 (1-50 μM; 24 h) specifically inhibits homologous recombination (HR) in U2OS cells and stimulates single-strand annealing (SSA) in HEK293 cells. RI-1 (5-20 μM; 30 min) inhibits HsRAD51 in a concentration-dependent manner. RI-1 (20 μM; 8 h) disrupts the formation of RAD51 foci after DNA damage in immortalized human fibroblasts. RI-1 (15-25 μM; 24 h) sensitizes human cancer cells (HeLa, MCF-7 and U2OS) to cross-linking chemotherapy.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

RI-1 | RI1 | RI 1

Quick Database Links

Gene Symbol

DNA/RNA Synthesis