Rhapontigenin

SKU: orb1303764

Description

Rhapontigenin is a natural stilbenoid and resveratrol analog that acts as a potent, mechanism-based inactivator of cytochrome P450 1A1 (IC50: 400 nM), inhibiting the metabolic activation of procarcinogens. It exhibits antioxidant properties and demonstrates anti-proliferative activity against various cancer cell lines, such as HL-60 and HepG2, in vitro, supporting research in chemoprevention and oncology.

Research Area

Infectious Disease & Virology, Metabolism Research

Key Properties

• CAS Number: 500-65-2
• MW: 258.27
• Purity: 99.36% (May vary between batches)
• Formula: C₁₅H₁₄O₄
• SMILES: COc1ccc(\C=C\c2cc(O)cc(O)c2)cc1O
• Target: Antifungal|||Antibacterial|||Cytochromes P450
• Solubility: Chloroform, Dichloromethane, Ethyl Acetate, Acetone, etc.:Soluble;DMSO:131.25 mg/mL (508.19 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (7.74 mM)

Bioactivity

• Target IC50:
  HL-60R:48 μM|HepG2 cells:48 μM|CYP1A1:400 nM

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

inhibit, Fungal, hypoglycemic, Inhibitor, Bacterial, anticoagulative, antiangiogenic, antiallergic, CYPs, CYP1A1, Cytochrome P450, purgative, Rhapontigenin, Protigenin

Compound Identifiers

PubChem CID

5320954