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Rhapontigenin

SKU: orb1222161

Description

Rhapontigenin is a mechanism-based, selective inactivator of cytochrome P450 1A1 (IC50: 400 nM), an aryl hydrocarbon hydroxylase which activates polycyclic aromatic hydrocarbons that act as procarcinogens. Rhapontigenin is a natural analog of resveratrol with antioxidant and anti-cancer activity. At higher concentrations, rhapontigenin inhibits the proliferation of HL-60R and HepG2 cancer cell lines (IC50: 48 μM).

Images & Validation

Key Properties

CAS Number500-65-2
MW258.3
Purity>98% (HPLC)
FormulaC15H14O4
SMILESCOc1c(cc(cc1)/C=C/c1cc(cc(c1)O)O)O
TargetAChR
SolubilityIn Vitro: DMSO : 125 mg/mL (483.99 mM)

Bioactivity

In Vivo
Animal model: ICR mice. Dosage: 25 mg/kg. Administration: 25 mg/kg; intraperitoneal injection. Result: Showed anti-thrombosis activity with 60% protection.

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

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Rhapontigenin (orb1222161)

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(Recommended: An additional animal making an allowance for loss during the experiment)

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200 mg
500 mg
5 mg
$ 160.00
10 mg
$ 270.00
25 mg
$ 490.00
50 mg
$ 720.00
100 mg
$ 890.00