RG7834

SKU: orb1309162

Description

RG7834 (RO 7020322) is a potent, orally bioavailable small-molecule inhibitor of hepatitis B virus, demonstrating low nanomolar IC50 values against HBsAg, HBeAg, and HBV DNA in dHepaRG cell assays. It serves as a valuable research tool for investigating HBV replication mechanisms and evaluating antiviral strategies in both in vitro and in vivo models.

Research Area

Infectious Disease & Virology

Key Properties

• CAS Number: 2072057-17-9
• MW: 401.45
• Purity: 99.89% (May vary between batches)
• Formula: C₂₂H₂₇NO₆
• SMILES: COCCCOc1cc2C[C@@H](C(C)C)n3cc(C(O)=O)c(=O)cc3-c2cc1OC
• Target: HBV
• Solubility: DMSO:125 mg/mL (311.37 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (9.96 mM)

Bioactivity

• Target IC50:
  HBV DNA:3.2 nM |HBsAg:2.8 nM |HBeAg:2.6 nM
• In Vivo:
  In HBV-infected human liver chimeric uPA-SCID mice,RG7834 shows anti-HBV efficacy. RG7834 (2, 14.5 mg/kg, p.o.) exhibits good oral bioavail ability, and with a half-life of 4.9 h in mice.
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• In Vitro:
  RG7834 ((S)-(+)-64) is a highly selective and orally bioavailable inhibitor of HBV, potently inhibiting HBV antigens (HBsAg and HBeAg) and HBV DNA with IC50s of 2.8, 2.6, and 3.2 nM, respectively, in dHepaRG cells. RG7834 exhibits no activity against CYP3A4, CYP2D6, CYP2C9 (IC50s >50 μM) or the hERG channel.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

inhibit, HBsAg, HBV, HBV DNA, HBeAg, Hepatitis B virus, Inhibitor, RO 7020322, RO7020322, RO-7020322, RG 7834, RG7834, RG-7834

Compound Identifiers

PubChem CID

118261815