RG7834

SKU: orb1218488

Description

RG7834 is a highly selective and orally bioavailable inhibitor of HBV(HBsAg and HBeAg and HBV DNA with IC50s of 2.8, 2.6, and 3.2 nM, respectively, in dHepaRG Cells).

Key Properties

• CAS Number: 2072057-17-9
• MW: 401.45
• Purity: >98% (HPLC)
• Formula: C₂₂H₂₇NO₆
• SMILES: CC(C)[C@@H]1CC2=CC(=C(C=C2C3=CC(=O)C(=CN13)C(=O)O)OC)OCCCOC
• Target: HBV
• Solubility: DMSO:125 mg/mL (311.37 mM; Need ultrasonic)

Bioactivity

• In Vivo:
  RG7834 (4 mg/kg, twice daily for 21 days) shows anti-HBV efficacy in HBV-infected human liver chimeric uPA-SCID mice. RG7834 (2, 14.5 mg/kg, p.o.) exhibits good oral bioavail ability, with a half-life of 4.9 h in mice. Animal model: HBV-infected human liver chimeric uPA-SCID mice. Dosage: 4 mg/kg. Administration: Twice daily for 21 days. Result: Reduced both HBsAg and HBeAg, also decreased serum HBV DNA by 0.6 log10 in mice.
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• In Vitro:
  RG7834 ((S)-(+)-64) is a highly selective and orally bioavailable HBV inhibitor, potently inhibits HBV antigens (both HBsAg and HBeAg) and HBV DNA, with IC50s of 2.8, 2.6, and 3.2 nM, respectively, in dHepaRG Cells. RG7834 has no activity against CYP3A4, CYP2D6, CYP2C9 (IC50s >50 μM) or hERG channel.
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Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

RO 7020322

Quick Database Links

Gene Symbol

HBV