RG 14620

SKU: orb1222729

Description

RG-14620 is an EGFR inhibitor. It is a non-phenolic tyrphostin analog, which is selective for the EGF receptor and long acting. It inhibits EGF-stimulated HER14 cell proliferation (IC50=3 μM) as well as tumor growth in vivo.

Key Properties

• CAS Number: 136831-49-7
• MW: 275.13
• Purity: >98% (HPLC)
• Formula: C₁₄H₈Cl₂N₂
• SMILES: c1cc(cnc1)/C(=C\c1cc(cc(c1)Cl)Cl)/C#N
• Target: HER14 colony formation| HER14 DNA synthesis
• Solubility: DMSO : ≥ 26 mg/mL; 94.50 mM

Bioactivity

• In Vivo:
  RG14620, at a dose of 200 g/mouse/day inhibits H-85 tumor growth in nude mice. Mice show less cachexia and hypercalcemia, eat more food, and are more active than untreated MH-85 tumor-bearing animals.
• In Vitro:
  RG14620 inhibits colony formation (IC50 = 3 μM) and DNA synthesis (IC50 = 1 μM) by HER 14 cells, which are stimulated by 50 ng/mL EGF, in a dose-dependent manner. RG14620 also suppresses colony formation(IC50 = 4 μM) and DNA synthesis (IC50 = 1.25 μM) by EGF-stimulated MH-85 cells in a dose-dependent manner. The growth-inhibitory effect of RG14620 irreversible.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

RG 14620 | TYRPHOSTIN RG 14620.

Quick Database Links

Gene Symbol

HER14 colony formation| HER14 DNA synthesis