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Catalog Number | orb386169 |
---|---|
Category | Antibodies |
Description | Recognizes a 105kDa phosphoprotein, identified as retinoblastoma (Rb) gene product. It shows no cross reaction with p107 or p130. It specifically stains the nuclei of BT-20 cells and primary human foreskin fibroblast (HFF) cells. It does not stain the Rb-negative BT549 cells. It reacts with the hyperphosphorylated as well as the un (under) phosphorylated form of the Rb protein. Retinoblastoma gene product plays a key role in cell cycle control. It has been identified as a tumor suppressor gene whose loss of its function leads to tumor development. It is widely expressed in a variety of human tissues including breast, esophageal, squamous cell and cervical carcinoma. |
Species/Host | Mouse |
Clonality | Monoclonal |
Clone Number | SPM353 |
Tested applications | IHC-P |
Reactivity | Human |
Isotype | Mouse IgG1, kappa |
Immunogen | A human recombinant partial protein was used as the immunogen for this Retinoblastoma antibody. |
Dilution range | Immunohistochemistry (FFPE): 1-2ug/ml for 30 min at RT |
Purity | Protein G affinity chromatography |
Conjugation | Unconjugated |
Formula | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide |
Hazard Information | This Retinoblastoma antibody is available for research use only. |
UniProt ID | P06400 |
Storage | The Retinoblastoma antibody (with azide) can be stored at 2-8°C. The azide-free format should be aliquoted and stored at -20°C or colder. |
Buffer/Preservatives | 0.2 mg/ml in 1X PBS with 0.1 mg/ml rAlbumin (US sourced) and 0.05% sodium azide |
Note | For research use only |
Application notes | Titering of the Retinoblastoma antibody may be required for optimal performance. |
Expiration Date | 12 months from date of receipt. |
Immunohistochemical staining of Human colon using Retinoblastoma antibody
IHC-P, IP, WB | |
Human, Mouse | |
Mouse | |
Monoclonal | |
Unconjugated |
IHC-P | |
Human, Mouse | |
Rabbit | |
Recombinant | |
Unconjugated |
IHC-P | |
Human, Mouse | |
Mouse | |
Monoclonal | |
Unconjugated |
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