Rebeprazole sodium

SKU: orb1226867

Description

Rebeprazole sodium is a proton pump inhibitor.(In Vitro):Rabeprazole attenuates the cell viability of the human gastric cancer cells following treatment with 0.2 mM for 16 hours.Rabeprazole completely inhibits the phosphorylation of ERK1/2 in the MKN-28 cells. The gastric cancer cell line MKN-28 is cultured in acidic culture media (pH 5.4) for 2 hours. Pretreatment with Rabeprazole (0.2 mM for 2 hours) leads to strong inhibition of ERK 1/2 phosphorylation in the MKN-28 cells.(In Vivo):Rabeprazole (10 mg/kg; P.O.; every 48 h for 18 weeks) course leads to a significant decline in bone mineral density (BMD) and decreases serum calcium level and produces secondary hyperparathyroidism in female mice.

Key Properties

• CAS Number: 117976-90-6
• MW: 381.42
• Purity: >98% (HPLC)
• Formula: C₁₈H₂₀N₃NaO₃S
• SMILES: [Na+].COCCCOC1=C(C)C(CS(=O)C2=NC3=CC=CC=C3[N-]2)=NC=C1
• Target: Proton Pump
• Solubility: DMSO: 76mg/ml(199.26 mM);Water: 76mg/ml(199.26 mM);Ethanol: 76mg/ml(199.26 mM)

Bioactivity

• In Vivo:
  Animal model: Female Swiss albino mice (body weight equals 18-26 g). Dosage: 10 mg/kg. Administration: Oral administration; every 48 h for 18 weeks. Result: Showed significantly lower serum calcium level compared to the vehicle treated group (5.5±2.07 vs. 9.68±2.77).

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

E 3810 | LY307640

Quick Database Links

Gene Symbol

Proton Pump