Rabeprazole sodium

SKU: orb1307891

Description

Rabeprazole Sodium is a proton pump inhibitor derived from timoprazole, used to treat gastric ulcers and Zollinger-Ellison syndrome by inhibiting H+/K+ ATPase in parietal cells. It is widely applied in pharmacological research for investigating gastric acid secretion in both in vitro cellular models and in vivo animal studies.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 117976-90-6
• MW: 381.42
• Purity: 99.91% (May vary between batches)
• Formula: C₁₈H₂₀N₃NaO₃S
• SMILES: c12c([n-]c(n1)S(=O)Cc1c(c(ccn1)OCCCOC)C)cccc2.[Na+]
• Target: Proton pump,Apoptosis,Antibacterial
• Solubility: Ethanol:71 mg/mL (186.15 mM);H2O:1.34 mg/mL (3.51 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.24 mM);DMSO:58.82 mg/mL (154.21 mM)

Bioactivity

• Target IC50:
  UNH:0.3 μM (IC50)
• In Vivo:
  Rabeprazole does not appear to exacerbate bone metabolic disorders in gastrectomized rats, but rather ameliorates the TG-induced BMD decrease.
• In Vitro:
  Administration of rabeprazole leads to a marked decrease in the viability of MKN-28 cells. Exposure to rabeprazole induces significant apoptosis in AGS cells. Rabeprazole completely inhibits the phosphorylation of ERK 1/2 in the MKN-28 cells, whereas the same effect is not observed in either the KATO III or MKN-45 cells. Rabeprazole is able to efficaciously inhibit the phosphorylation of ERK 1/2 in the gastric cancer cells.Thus, rabeprazole can attenuate the cell viability of human gastric cancer cells through inactivation of the ERK1/2 signaling pathway.
• Cell Research:
  Rabeprazole is administrated to three gastric cancer cell lines, KATO III, MKN-28 and MKN-45, at a dosage of 0.2 mM for 16 h. The viability of these cells is determined by a trypan blue exclusion assay.(Only for Reference)

Storage & Handling

• Storage: store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Aciphex Sodium, Apoptosis, Dexrabeprazole Sodium, nucleoside, LY307640, LY307640 sodium, LY-307640, LY 307640, Habeprazole Sodium, gastroesophageal, gastric, reflux, Rebeprazole sodium, PPI, Rabeprazole, Rabeprazole sodium, proton, Protonpump, Proton pump, Proton Pump, pump, ribohydrolase, ulcerations, UNH

Quick Database Links

Gene Symbol

Proton pump,Apoptosis,Antibacterial