Rabeprazole sodium

SKU: orb1307891

Description

Rabeprazole Sodium is a proton pump inhibitor derived from timoprazole, used to treat gastric ulcers and Zollinger-Ellison syndrome by inhibiting H+/K+ ATPase in parietal cells. It is widely applied in pharmacological research for investigating gastric acid secretion in both in vitro cellular models and in vivo animal studies.

Research Area

Cell Biology, Infectious Disease & Virology, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 117976-90-6
• MW: 381.42
• Purity: 99.91% (May vary between batches)
• Formula: C₁₈H₂₀N₃NaO₃S
• SMILES: c12c([n-]c(n1)S(=O)Cc1c(c(ccn1)OCCCOC)C)cccc2.[Na+]
• Target: Apoptosis,Proton pump,Antibacterial
• Solubility: Ethanol:71 mg/mL (186.15 mM);H2O:1.34 mg/mL (3.51 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.24 mM);DMSO:58.82 mg/mL (154.21 mM)

Bioactivity

• Target IC50:
  UNH:0.3 μM (IC50)
• In Vivo:
  Rabeprazole does not appear to exacerbate bone metabolic disorders in gastrectomized rats, but rather ameliorates the TG-induced BMD decrease.
• In Vitro:
  Administration of rabeprazole leads to a marked decrease in the viability of MKN-28 cells. Exposure to rabeprazole induces significant apoptosis in AGS cells. Rabeprazole completely inhibits the phosphorylation of ERK 1/2 in the MKN-28 cells, whereas the same effect is not observed in either the KATO III or MKN-45 cells. Rabeprazole is able to efficaciously inhibit the phosphorylation of ERK 1/2 in the gastric cancer cells.Thus, rabeprazole can attenuate the cell viability of human gastric cancer cells through inactivation of the ERK1/2 signaling pathway.
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• Cell Research:
  Rabeprazole is administrated to three gastric cancer cell lines, KATO III, MKN-28 and MKN-45, at a dosage of 0.2 mM for 16 h. The viability of these cells is determined by a trypan blue exclusion assay.(Only for Reference)
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Aciphex Sodium, Apoptosis, Dexrabeprazole Sodium, nucleoside, LY307640, LY307640 sodium, LY-307640, LY 307640, Habeprazole Sodium, gastroesophageal, gastric, reflux, Rebeprazole sodium, PPI, Rabeprazole, Rabeprazole sodium, proton, Protonpump, Proton pump, Proton Pump, pump, ribohydrolase, ulcerations, UNH

Quick Database Links

Gene Symbol

Apoptosis,Proton pump,Antibacterial