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RBN-3143

SKU: orb2900624

Description

RBN-3143 is a potent and NAD+-competitive catalytic PARP14 inhibitor with an IC50 value of 4 nM. RBN-3143 inhibits PARP14-mediated ADP-ribosylation and stabilizes PARP14 in cell lines. RBN-3143 can be used in research of lung inflammation.

Images & Validation

Key Properties

CAS Number2360853-16-1
MW449.54
Purity>98% (HPLC)
FormulaC22H28FN3O4S
SMILESCC(=O)N1CCC(COc2cc(F)c3c(c2)nc(CSC2CCOCC2)[nH]c3=O)CC1
TargetPARP
SolubilityIn Vitro: DMSO : 25 mg/mL (55.61 mM; Ultrasonic (<60°C)

Bioactivity

In Vivo
Animal model: Mouse of asthma models. Dosage: 5 ug. Administration: Intranasal administration. Result: Suppressed the accumulation of alarmins TSLP, IL-33, and IL-25.

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

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  • RBN-3143 [orb1685567]

    98.64% (May vary between batches)

    2360853-16-1

    449.54

    C22H28FN3O4S

    1 ml x 10 mM (in DMSO), 200 mg, 25 mg, 50 mg, 1 mg, 5 mg, 10 mg, 100 mg
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Protocol Information

RBN-3143 (orb2900624)

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(Recommended: An additional animal making an allowance for loss during the experiment)

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Available Sizes

Select a size below

2 mg
$ 210.00
5 mg
$ 320.00
10 mg
$ 450.00
25 mg
$ 730.00
50 mg
$ 1,050.00
100 mg
$ 1,430.00
500 mg
$ 2,850.00