RBN-3143

SKU: orb1685567

Description

RBN-3143 is a potent, NAD+-competitive PARP14 inhibitor (IC50= 4 nM) that blocks ADP-ribosylation and stabilizes the protein in cellular models. It shows research utility for studying PARP14's role in contexts such as lung inflammation, based on findings from in vitro and in vivo investigations.

Research Area

Epigenetics & Chromatin, Molecular Biology

Key Properties

• CAS Number: 2360853-16-1
• MW: 449.54
• Purity: 98.64% (May vary between batches)
• Formula: C₂₂H₂₈FN₃O₄S
• SMILES: CC(=O)N1CCC(COc2cc(F)c3c(c2)nc(CSC2CCOCC2)[nH]c3=O)CC1
• Target: PARP
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.45 mM);DMSO:11.2 mg/mL (24.91 mM)

Bioactivity

• Target IC50:
  PARP10:1600 nM|PARP1:>100000 nM|PARP4:42700 nM|PARP3:>100000 nM|PARP14:4 nM|PARP2:>100000 nM|PARP15:4200 nM
• In Vivo:
  RBN-3143 (5 μg; Intranasal administration) can improve the steroid resistant asthma mouse model .

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

PARP14, RBN3143, RBN-3143, RBN 3143

Compound Identifiers

PubChem CID

138697188