Rasagiline mesylate

SKU: orb1300309

Description

Rasagiline Mesylate (AGN1135) is a selective MAO-B inhibitor used in research for Parkinson's disease. It is applied in both in vitro enzymatic studies and in vivo models to investigate neuroprotective mechanisms and dopaminergic function.

Research Area

Neuroscience

Key Properties

• CAS Number: 161735-79-1
• MW: 267.34
• Purity: >98%
• Formula: C₁₂H₁₃N ∙ CH₃SO₃H
• SMILES: C#CCN[C@@H]1CCc2ccccc12.CS(=O)(=O)O
• Target: Monoamine oxidase
• Solubility: Soluble in DMSO (up to 50 mg/ml), in Water (up to 50 mg/ml) or in Ethanol (up to 30 mg/ml)

Bioactivity

• Target IC50:
  MAO-A:412 nM|MAO-B:4.43 nM
• In Vivo:
  Rasagiline ex vivo inhibits MAO in the brain and liver with ED50 of 4.43 nM and 412 nM, respectively. Rasagiline (0.2 mg/kg and 1 mg/kg) accelerates the recovery of motor function and spatial memory and reduces the cerebral oedema by about 40-50% in the mouse.
• In Vitro:
  Rasagiline inhibits rat brain MAO type B and type A with IC50 of 4.43 nM and 412 nM, respectively. Rasagiline is three to 15 times more potent than selegiline for inhibition of MAO-B in rat brain and liver in vivo on acute and chronic administration, but has similar potency in vitro. Rasagiline prevents nuclear accumulation of GAPDH induced by N-methyl(R) salsolinol in SH-SY5Y cells. Rasagiline prevents the collapse in ΔΨm, and following apoptotic process, which indicates that mitochondria may determine the survival and death of the cells. Rasagiline has potent antiapoptotic and neuroprotective activities in response to serum and NGF withdrawal in partially neuronally differentiated PC12 cells and prevents the fall in mitochondrial membrane potential, the first step in cell death. Rasagiline is metabolized to its major metabolite aminoindan, selegiline gives rise to L-methamphetamine. Rasagiline directly activates PKC-MAP kinase pathway by a concentration and time dependent phosphorylation of p42 and p44 MAP kinase.

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

TVP-1012; Azilect

Compound Identifiers

PubChem CID

3052775