Rasagiline Mesylate

SKU: orb1226048

Description

Rasagiline Mesylate is a new MAO-B inhibitor for the treatment of idiopathic Parkinson's disease.(In Vitro):Rasagiline (0.25 nM; 96 hours) significantly increases the proliferation rates of SH-SY5Y and 1242-MG upon Dexamethasone (10 μM) treatment.(In Vivo):Rasagiline is neuroprotective in a transgenic model of multiple system atrophy. Motor behavioural tests show improvements in motor deficits associated with 2.5 mg/kg Rasagiline therapy.

Key Properties

• CAS Number: 161735-79-1
• MW: 267.34
• Purity: >98% (HPLC)
• Formula: C₁₃H₁₇NO₃S
• SMILES: CS(=O)(=O)O.C#CCN[C@@H]1CCC2=CC=CC=C12
• Target: MAO
• Solubility: Soluble in water

Bioactivity

• In Vivo:
  Rasagiline is neuroprotective in a transgenic model of multiple system atrophy. Motor behavioural tests show improvements in motor deficits associated with 2.5 mg/kg Rasagiline therapy. Animal model: (PLP)-α-synuclein transgenic mice over 6 months of age. Dosage: Low-(0.8 mg/kg b. w.) and high dose (2.5 mg/kg b. w.). Administration: Administered subcutaneously every 24 h for a total period of 4 weeks (from day 1 till day 28 of the experiment). Result: Low dose treatment did not show protective efficacy in striatum with number of neurons similar to placebo treated MSA mice. High dose was associated with about 15% rescue of DARPP-32 immunoreactive striatal neurons. Low dose treatment had no effect on nigral neuronal loss, but high dose completely protected nigral neurons with numbers comparable to healthy controls.
• In Vitro:
  Rasagiline (0.25 nM; 96 hours) significantly increases the proliferation rates of SH-SY5Y and 1242-MG upon Dexamethasone (10 μM) treatment. Cell Viability Assay Cell line: Neuroblastoma SH-SY5Y, and glioblastoma 1242-MG. Concentration: 0.25 nM Incubation time: 96 hours. Result: Caused ~60% increase in the cell proliferation rate for SH-SY5Y cells treated with Dexamethasone. Caused ~35% increase in cell proliferation rate for 1242-MG cells treated with Dexamethasone.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

MAO