Rapanone

SKU: orb1297074

Description

Rapanone

Research Area

Cell Biology, Infectious Disease & Virology, Metabolism Research

Key Properties

• CAS Number: 573-40-0
• MW: 322.44
• Purity: 99.72%
• Formula: C₁₉H₃₀O₄
• SMILES: CCCCCCCCCCCCCC1=C(O)C(=O)C=C(O)C1=O
• Target: Apoptosis,Antibacterial,Phospholipase,Parasite
• Solubility: DMSO:65 mg/mL (201.59 mM);10% DMSO+90% Corn Oil:2.5 mg/mL (7.75 mM)

Bioactivity

• Target IC50:
  PLA2:2.6 μM
• In Vivo:
  In mice,rapanone (2.5-10 mg/kg; i.p.) exhibits anti-inflammatory effects in the carrageenan paw oedema model
• In Vitro:
  In the HepG2, rapanone (20–40 μM) induced a concentration-dependent mitochondrial membrane potential dissipation, ATP depletion, hydrogen peroxide generation and, phosphatidyl serine externalization.Rapanone impairs mitochondrial respiration by inhibiting electron transport chain at Complex III and promotes mitochondrial dysfunction.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

benzoquinone, 2,5-Dihydroxy-3-tridecyl-[1,4]benzoquinone, 2,5-Dihydroxy-3-tridecylcyclohexa-2,5-diene-1,4-dione, antioxidant, antiparasiti, anti-inflammatory, antibacterial, Apoptosis, anti-tumor, Bacterial, inhibit, Parasite, Inhibitor, synovial, PLA2, Phospholipase, Rapanone

Compound Identifiers

PubChem CID

100659