Rapanone

SKU: orb1217863

Description

Rapanone is a natural benzoquinone that is a potent and selective inhibitor of human synovial PLA2.

Key Properties

• CAS Number: 573-40-0
• MW: 322.44
• Purity: >98% (HPLC)
• Formula: C₁₉H₃₀O₄
• SMILES: CCCCCCCCCCCCCC(C(C(O)=CC1=O)=O)=C1O
• Target: Phospholipase
• Solubility: In Vitro: DMSO : 25 mg/mL (77.53 mM)

Bioactivity

• In Vivo:
  Rapanone (2.5-10 mg/kg; i.p.) exhibits anti-inflammatory effects in the carrageenan paw oedema model in mice.
• In Vitro:
  Rapanone (10-40 μM; 24 h) inhibits the cell viability, with IC50s of 35.58 μM and 27.89 μM for primary rats hepatocytes and HepG2 cells, respectively. Rapanone (10-40 μM; 24 h) induces a concentration-dependent mitochondrial membrane potential dissipation, ATP depletion, hydrogen peroxide generation and, phosphatidyl serine externalization in HepG2 cells. Rapanone inhibits electron transport at Complex III and promotes mitochondrial dysfunction.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

2,5-Dihydroxy-3-tridecylcyclohexa-2,5-diene-1,4-dione | 2,5-Dihydroxy-3-tridecyl-[1,4]benzoquinone

Quick Database Links

Gene Symbol

Phospholipase