Raloxifene

SKU: orb1705643

Description

Raloxifene is a selective estrogen receptor modulator (SERM) with demonstrated antiviral activity against viruses such as Ebola, influenza, and HCV. It is a valuable research tool for studying viral pathogenesis and screening antiviral agents in both in vitro and in vivo experimental models.

Research Area

Metabolism Research, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 84449-90-1
• MW: 473.58
• Purity: 99.87% (May vary between batches)
• Formula: C₂₈H₂₇NO₄S
• SMILES: O=C(C1=CC=C(OCCN2CCCCC2)C=C1)C3=C(SC4=CC(O)=CC=C43)C=5C=CC(O)=CC5
• Target: Estrogen Receptor/ERR
• Solubility: Ethanol:9 mg/mL (19 mM);DMSO:80 mg/mL (168.93 mM)

Bioactivity

• In Vivo:
  Raloxifene (10 mg/kg) induced significant reductions of urea and creatinine, TNF-α, IL-1β and caspase-3 in renal isis-reperfusion injury mouse models, suggesting renal protection. Treatment with Raloxifene (10 mg/kg) alleviates vision defects caused by initial cell injury (OBI) and may be associated with a reduction in the proinflammatory effects of microglia.
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• In Vitro:
  Raloxifene (10 μM and 50 μM) treated cells showed an increase in the percentage of cells with fragmented nuclei of 31 to 41 percent and 45 to 66 percent, respectively, after 12 and 24 hours of exposure. Treatment with Raloxifene (50 μM) resulted in increased autophagy activity in host cells, helping to prevent intracellular bacterial invasion and proliferation. Treatment with Raloxifene((40-100 μM) prevented the dissolution of stress particles (SG) and promoted cell death during hypoxia of U251 and U3024 primary glioblastoma (GBM) cells.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

breast, cancer, bone, osteoporosis, ovariectomized, inhibit, Keoxifene, LY156758, LY-156758, LY156758 free base, LY139481, LY-139481, LY1 39481, LY 156758, LY 139481, loss, ERR, Estrogen Receptor/ERR, EstrogenReceptor, Estrogen Receptor, Inhibitor, SERM, Raloxifene, Raloxifenum, Pharoxifene, rats

Compound Identifiers

PubChem CID

5035