RafRBD (c-Raf)

SKU: orb533577

Description

Raf is a member of the serine/threonine proteine kinase family involved in regulation of cell growth and differentiation and is the most important effector of Ras. Full-length Raf is composed of three conserved regions responsible for interaction with Ras, for phos-phorylation and for catalytic activity. RafRBD (Ras binding domain, amino acids 50-132) mediates interaction with membrane-anchored Ras necessary for activation of the kinase activity of Raf.

Research Area

Signal Transduction

Key Properties

• Source: E. coli
• Biological Origin: human
• MW: Theoretical MW: 9.4 kDa (50-132 amino acids)
• Purity: > 90% (SDS-PAGE)

Storage & Handling

• Storage: store at -80 °C
• Form/Appearance: liquid (Supplied in 32 mM Tris-HCl pH 7.6, 200 mM NaCl, 5 mM MgCl 2and 5 mM DTT)
• Expiration Date: 6 months from date of receipt.
• Dry Ice Shipping: Please note: This product requires shipment on dry ice. A dry ice surcharge will apply.
• Disclaimer: For research use only

Alternative Names

Ras Binding Domain of Raf, c-Raf 1 Kinase, human, recombinant, E. coli