(R)-Propranolol hydrochloride

SKU: orb1940479

Description

Dexpropranolol hydrochloride is the less active enantiomer of the anti-adrenoceptor (β-adrenoceptor) antagonist propranolol. Propranolol is a nonselective β-adrenergic receptor (βAR) antagonist with a high affinity for β1AR and β2AR with Ki values of 1.8 nM and 0.8 nM, respectively.(In Vivo):Both isomers of propranolol are capable of preventing adrenaline-induced cardiac arrhythmias in cats anaesthetized with halothane and reversing ventricular tachycardia caused by ouabain in anaesthetized cats and dogs, but the dose of (-)-propranolol is significantly smaller than that of (+)-propranolol ((R)-Propranolol) in both species. Administration of 10 mg/kg (R)-Propranolol hydrochloride has no antagonistic activity in rats, the cardiac responses to isoprenaline of rats can be blocked by probably much less than 1/100th of that of the (-) isomer in this preparation.

Key Properties

• CAS Number: 13071-11-9
• MW: 295.81
• Purity: >98% (HPLC)
• Formula: C₁₆H₂₂ClNO₂
• SMILES: Cl.CC(C)NC[C@@H](O)COc1cccc2ccccc12
• Target: Adrenergic Receptor
• Solubility: In Vitro: DMSO : 250 mg/mL (845.17 mM)

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Dexpropranolol hydrochloride | (R)-(+)-Propranolol

Quick Database Links

Gene Symbol

Adrenergic Receptor