(R)-Propranolol hydrochloride

SKU: orb1306504

Description

Dexpropranolol hydrochloride is the less active (R)-enantiomer of propranolol, a non-selective β-adrenergic receptor antagonist with high affinity for both β1AR (Ki=1.8 nM) and β2AR (Ki=0.8 nM). It is used as a pharmacological tool in cardiovascular and neuroscience research for in vitro and in vivo studies of β-adrenoceptor function.

Research Area

Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 13071-11-9
• MW: 295.8
• Purity: 98.63%
• Formula: C₁₆H₂₂ClNO₂
• SMILES: Cl.CC(C)NC[C@@H](O)COc1cccc2ccccc12
• Target: Adrenergic Receptor
• Solubility: DMSO:250 mg/mL (845.17 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (6.76 mM);H2O:14.79 mg/mL (50 mM)

Bioactivity

• Target IC50:
  β1-adrenoceptor:1.8 nM(Ki)|β2-adrenoceptor:0.8 nM(Ki)
• In Vivo:
  Both isomers of propranolol are capable of preventing adrenaline-induced cardiac arrhythmias in cats anaesthetized with halothane and reversing ventricular tachycardia caused by ouabain in anaesthetized cats and dogs, but the dose of (-)-propranolol is significantly smaller than that of (+)-propranolol ((R)-Propranolol) in both species. Administration of 10 mg/kg (R)-Propranolol hydrochloride has no antagonistic activity in rats, the cardiac responses to isoprenaline of rats can be blocked by probably much less than 1/100th of that of the (-) isomer in this preparation.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

β-adrenoceptor, Propranolol, Propranolol Hydrochloride, cardiac arrhythmias, Beta Receptor, Dexpropranolol hydrochloride, Dexpropranolol Hydrochloride, AdrenergicReceptor, Adrenergic Receptor, (R)-Propranolol, (R)Propranolol hydrochloride, (R) Propranolol hydrochloride, (R)-(+)-Propranolol, enantiomer, inhibit, Inhibitor

Compound Identifiers

PubChem CID

66366