(R)-Elagolix

SKU: orb1217613

Description

(R)-Elagolix is a short-acting, nonpeptide, GnRH antagonist with an IC50 and Ki of 0.25 and 3.7 nM, respectively. administered orally, that unlike injectable depot GnRH agonists and antagonists, produces a dose-dependent suppression of ovarian estrogen production, that is, from partial suppression at lower doses to full suppression at higher doses.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 834153-87-6
• MW: 631.59
• Purity: >98% (HPLC)
• Formula: C₃₂H₃₀F₅N₃O₅
• SMILES: CC1=C(C(=O)N(C(=O)N1CC2=C(C=CC=C2F)C(F)(F)F)C[C@@H](C3=CC=CC=C3)NCCCC(=O)O)C4=C(C(=CC=C4)OC)F
• Target: GnRHR
• Solubility: DMSO:100 mg/mL (158.33 mM)

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

NBI-56418

Quick Database Links

Gene Symbol

GnRHR