(R)​-​CR8

SKU: orb1309189

Description

(R)-CR8 is the enantiomerically pure R-isomer of a potent and selective cyclin-dependent kinase (CDK) inhibitor. It is widely used in biochemical and cellular research to study cell cycle progression, transcription, and neuronal apoptosis, with applications demonstrated in both in vitro assays and in vivo model systems.

Research Area

Cell Biology, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 294646-77-8
• MW: 431.53
• Purity: 98.41% (May vary between batches)
• Formula: C₂₄H₂₉N₇O
• SMILES: CC[C@H](CO)Nc1nc(NCc2ccc(cc2)-c2ccccn2)c2ncn(C(C)C)c2n1
• Target: Apoptosis|||CDK
• Solubility: DMSO:11 mg/mL (25.49 mM)

Bioactivity

• Target IC50:
  CDK1-CyclinB:0.09 μM|CDK9-CyclinT:0.18 μM|CK1δ/ε:0.4 μM|CDK2-CyclinA:0.072 μM|CDK7-CyclinH:1.1 μM|CDK5-p25:0.11 μM|CDK2-CyclinE:0.041 μM
• In Vivo:
  A delayed systemic post-LFP administration at 3 hours of CR8--a potent second-generation cyclin-dependent kinase (CDK) inhibitor--reduced CCA; cortical, hippocampal, and thalamic neuronal loss; and cortical microglial and astrocyte activation. Furthermore, CR8 treatment attenuated sensorimotor and cognitive deficits, alleviated depressive-like symptoms, and decreased lesion volume.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Isomer, lesion, Hippocampus, death, CK1δ/ε, cdk2/cyclin A, CDK2/cyclinE, Cdk1/cyclin B, CDK, CDK9/Cyclin T, Cdk5/p25, CDK7/cyclin H, cell, CR 8, CR8, CR-8, CR8, (R)-Isomer, Apoptosis, caspases, (R)-Isomer, (R)​ ​CR8, (R)​​CR8, (R)​-​CR-8, (R)?-?CR8

Compound Identifiers

PubChem CID

10224714