(R)-CR8 trihydrochloride

SKU: orb1708758

Description

(R)-CR8 trihydrochloride

Research Area

Cell Biology, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 1786438-30-9
• MW: 540.92
• Purity: 99.33%
• Formula: C₂₄H₃₂Cl₃N₇O
• SMILES: Cl.Cl.Cl.CC[C@H](CO)Nc1nc(NCc2ccc(cc2)-c2ccccn2)c2ncn(C(C)C)c2n1
• Target: Apoptosis,Molecular Glues,CDK
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (3.7 mM);DMSO:30 mg/mL (55.46 mM)

Bioactivity

• Target IC50:
  CDK2:0.072 μM|CDK5-p25:0.11 μM|CDK2-CyclinE:0.041 μM|CDK1:0.09 μM|CDK7-CyclinH:1.1 μM|CK1δ/ε:0.4 μM|CDK9-CyclinT1:0.18 μM
• In Vivo:
  In 10 to 12-week-old Male Sprague Dawley rats (310 to 330 g), administration of (R)-CR8 trihydrochloride at 5 mg/kg (i.p.) resulted in a significant reduction in lesion siz.
• In Vitro:
  I the SH-SY5Y cell line, (R)-CR8 trihydrochloride (0.1, 1, 10, 100 μM; 24 hours) reduced cell survival in a dose-dependent manne.

Storage & Handling

• Storage: keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Disclaimer: For research use only

Alternative Names

CR 8, CR 8 Trihydrochloride, CR8, CR-8, CR8 Trihydrochloride, CR-8 Trihydrochloride, CR8, (R)-Isomer trihydrochloride, CR8, Isomer, CR8, Isomer Trihydrochloride, CDK2, cdk2/cyclin A, CDK1, CDK1/cyclinB1, CDK9/Cyclin T, CDK5, CDK2/cyclinE, Cdk5/p25, CDK7, CDK7/cyclin H, CDK9, CK1δ/ε, (R)CR8 trihydrochloride, (R)-CR-8 trihydrochloride, (R)​-​CR8 trihydrochloride, (R) CR8 trihydrochloride, Apoptosis

Compound Identifiers

PubChem CID

90488866