(R)-(+)-Bay-K-8644

SKU: orb2900176

Description

(R)-(+)-Bay-K-8644 is a calcium channel inhibitor. (R)-(+)-Bay-K-8644 inhibits Ba2+ currents (IBa) (IC50=975 nM).

Key Properties

• CAS Number: 98791-67-4
• MW: 356.3
• Purity: >98% (HPLC)
• Formula: C₁₆H₁₅F₃N₂O₄
• SMILES: COC(=O)C1=C(C)NC(C)=C([C@@H]1c1ccccc1C(F)(F)F)[N+]([O-])=O
• Target: PPAR
• Solubility: In Vitro: DMSO : ≥ 300 mg/mL (841.99 mM)

Bioactivity

• In Vitro:
  (R)-(+)-Bay-K-8644, a conventional racemic mixture of Bay K 8644, is widely used as an L-type Ca2+ channel agonist. Each optical isomer possesses opposite effects on IBa, (R)-(+)-Bay-K-8644 as an antagonist and S(-)-Bay K 8644 as an agonist. (R)-(+)-Bay-K-8644 inhibits Ba2+ currents (IBa) (IC50 = 975 nM). When (R)-(+)-Bay-K-8644 (0.5 μM) is applied, IBa is suppressed to 71±10% of control. In the presence of (R)-(+)-Bay-K-8644IBa. (R)-(+)-Bay-K-8644 is a calcium channel inhibitor.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

PPAR