Quinoclamine

SKU: orb1307818

Description

Quinoclamine is a synthetic naphthoquinone compound that functions as an inhibitor of the NF-κB signaling pathway. It is utilized in biochemical research to study inflammatory responses and cellular signaling, with applications in both in vitro cell-based assays and in vivo experimental models.

Research Area

Signal Transduction

Key Properties

• CAS Number: 2797-51-5
• MW: 207.61
• Purity: 99.28% (May vary between batches)
• Formula: C₁₀H₆ClNO₂
• SMILES: NC1=C(Cl)C(=O)C2=C(C=CC=C2)C1=O
• Target: NF-κB
• Solubility: DMSO:50 mg/mL (240.84 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (9.63 mM)

Bioactivity

• In Vitro:
  Quinoclamine induces the differentiation of U-937 cells into macrophage-like cells. Quinoclamine inhibits NF-κB activities in HepG2 cells (IC50: 1.7 μM). Quinoclamine inhibits induced NF-κB activities in lung and breast cancer cell lines. Quinoclamine affects the expression levels of genes involved in cell cycle or apoptosis. Quinoclamine down-regulates the expressions of UDP glucuronosyltransferase genes involved in phase II drug metabolism. Quinoclamine (1-4 μM; 30 minutes ) inhibits endogenous NF-κB activity in HepG2 cells through the inhibition of IκB-α phosphorylation and p65 translocation .
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Nuclear factor-κB, Nuclear factor-kappaB, NF-κB, NFκB, NF-kB, NFkB, naphthoquinone, inhibit, Inhibitor, derivative, Quinoclamine

Compound Identifiers

PubChem CID

17748