Quinoclamine

SKU: orb1218231

Description

Quinoclamine is a naphthoquinone derivative and is an NF-κB inhibitor.

Key Properties

• CAS Number: 2797-51-5
• MW: 207.61
• Purity: >98% (HPLC)
• Formula: C₁₀H₆ClNO₂
• SMILES: C1=CC=C2C(=C1)C(=O)C(=C(C2=O)Cl)N
• Target: NF-κB
• Solubility: DMSO:250 mg/mL (1204.18 mM; Need ultrasonic)

Bioactivity

• In Vitro:
  Quinoclamine causes differentiation of U-937 cells into macrophage-like cells. Quinoclamine inhibits NF-κB activities in HepG2 cells, with an IC50 of 1.7 μM. Quinoclamine (1-4 μM; 30 minutes ) suppresses endogenous NF-κB activity in HepG2 cells through the inhibition of IκB-α phosphorylation and p65 translocation. Quinoclamine inhibits induced NF-κB activities in lung and breast cancer cell lines. Quinoclamine affects the expression levels of genes involved in cell cycle or apoptosis. Quinoclamine down-regulates the expressions of UDP glucuronosyltransferase genes involved in phase II drug metabolism. Cell Viability Assay Cell line: HepG2 cells. Concentration: 1 μM, 2 μM, 4 μM, 8 μM, 16 μM, 32 μM, 64 μM. Incubation time: 24 hours. Result: Inhibited NF-κB activities in HepG2 cells. Western blot analysis. Cell line: HepG2 cells. Concentration: 0 μM, 1 μM, 2 μM, 4 μM. Incubation time: 30 minutes. Result: Inhibited IκB-α phosphorylation and p65 translocation in HepG2 cells.
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Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

NF-κB