Quetiapine

SKU: orb1310882

Description

Quetiapine (ICI204636) is an atypical antipsychotic used in schizophrenia and bipolar I disorder research. Its mechanism involves antagonism of dopamine (D1, D2), serotonin (5-HT1A, 5-HT2), adrenergic (α1, α2), and histamine H1 receptors, making it a valuable tool for in vitro and in vivo neuropharmacology studies.

Research Area

Immunology & Inflammation, Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 111974-69-7
• MW: 383.51
• Purity: 99.71%
• Formula: C₂₁H₂₅N₃O₂S
• SMILES: OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2ccccc12
• Target: Dopamine Receptor,AChR,Histamine Receptor,Adrenergic Receptor,5-HT Receptor
• Solubility: H2O:< 1 mg/mL (insoluble or slightly soluble);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.21 mM);DMSO:120 mg/mL (312.9 mM)

Bioactivity

• Target IC50:
  5-HT2C receptor:5.55 (pKi)|D2 Receptor:6.33 (pIC50)|D2 Receptor:7.25 (pKi)|5-HT1A receptor:5.74 (pKi)|5-HT1A receptor:4.77 (pEC50)|5-HT2A receptor:7.54 (pKi)

Storage & Handling

• Storage: Pure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

DopamineReceptor, Dopamine Receptor, Dopamine, Antidepressant, anxiolytic, 5-HT2C, 5-HT Receptor, 5HT Receptor, 5-HT1A, 5-HT2A, Adrenergic Receptor, AdrenergicReceptor, 5-hydroxytryptamine Receptor, 5HTReceptor, 5-HT, H1 receptor, ICI204636, ICI-204636, ICI 204636, Inhibitor, Histamine Receptor, HistamineReceptor, inhibit, mAChR, Serotonin Receptor, Quetiapin, Quetiapine

Compound Identifiers

PubChem CID

5002