Quetiapine hemifumarate

SKU: orb1300946

Description

Quetiapine hemifumarate

Research Area

Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 111974-72-2
• MW: 883.09
• Purity: 100.00%
• Formula: C₄₆H₅₄N₆O₈S₂
• SMILES: OC(=O)\C=C\C(O)=O.OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2ccccc12.OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2ccccc12
• Target: Adrenergic Receptor,5-HT Receptor,Dopamine Receptor
• Solubility: DMSO:25 mg/mL (28.31 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (2.26 mM)

Bioactivity

• Target IC50:
  5 hT1A receptor:5.74 (pKi)|5 hT1A receptor:4.77 (pEC50)|5 hT2A receptor:7.54 (pKi)|D2 Receptor:7.25 (pKi)|D2 Receptor:6.33 ( IC50 |5 hT2C receptor:5.55 (pKi)
• In Vivo:
  Quetiapine has an affinity for dopamine-2 receptors similar to that of clozapine, and it exhibits comparable affinity for various neurotransmitter receptors, including serotonin, histamine, dopamine, and adrenergic receptors.
• In Vitro:
  Quetiapine alter the neurotransmitter norepinephrine in the brain's limbic system an the expression of c-fos. It also exhibits antipsychotic activity, diminishin the tendency to induce extrapyramidal symptoms and persistently increase prolactin levels. Its effectiveness in behavioral and biochemical assays mirrors that of clozapine, suggesting it may possess neur Protective properties.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Disclaimer: For research use only

Alternative Names

DopamineReceptor, Dopamine Receptor, Dopamine, 5HTReceptor, 5-hydroxytryptamine Receptor, 5HT Receptor, 5-HT2C, 5-HT1A, 5-HT Receptor, 5-HT2A, Adrenergic Receptor, AdrenergicReceptor, anxiolytic, Antidepressant, HT, ICI204636, ICI-204636, ICI 204636, Inhibitor, inhibit, Serotonin Receptor, Quetiapine hemifumarate, Quetiapine Hemifumarate, Quetiapine Fumarate, Quetiapine

Compound Identifiers

PubChem CID

5281025