Pyriproxyfen

SKU: orb1940698

Description

Pyriproxyfen is an insecticide that acts as a biomimetic of juvenile hormone.(In Vivo):Zebrafish male adults were acutely exposed to 0.001, 0.01 and 0.1 μg/mL pyriproxyfen for 16 h. Mitochondrial respiration of brain tissues was assessed. ROS generation was estimated using H2DCF-DA and MitoSOX. Calcium transport was monitored by Calcium Green 5 N. NO synthesis activity was estimated using DAF-FM-DA. Brain acetylcholinesterase showed an in vivo IC20 of 0.30 μmol/L pyriproxyfen, and an IC50 of 92.5 μmol/L. The inhibitory effect on zbAChE activity was competitive-like. Respiratory control of Complex I/II decreased significantly after insecticide exposure. The MitoSOX test showed that O2- generation had a pyriproxyfen dose-dependent effect. Brain tissue lost 50% of Ca2+ uptake capacity at 0.1 μg/mL pyriproxyfen. Ca2+ release showed a clear mitochondrial impairment at lower pyriproxyfen exposures.

Key Properties

• CAS Number: 95737-68-1
• MW: 321.376
• Purity: >98% (HPLC)
• Formula: C₂₀H₁₉NO₃
• SMILES: CC(COc1ccc(Oc2ccccc2)cc1)Oc1ccccn1
• Target: CDK4/CyclinD1
• Solubility: In Vitro: DMSO : ≥ 100 mg/mL (311.17 mM)

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

S-31183

Quick Database Links

Gene Symbol

CDK4/CyclinD1