Pyriproxyfen

SKU: orb1307824

Description

Pyriproxyfen

Research Area

Cell Biology, Infectious Disease & Virology

Key Properties

• CAS Number: 95737-68-1
• MW: 321.37
• Purity: 99.87%
• Formula: C₂₀H₁₉NO₃
• SMILES: O(C1=CC=C(OCC(OC2=CC=CC=N2)C)C=C1)C3=CC=CC=C3
• Target: Others,Parasite,Autophagy
• Solubility: DMSO:50 mg/mL (155.58 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (6.22 mM)

Bioactivity

• Target IC50:
  AChE:92.5 μmol/L(Zebrafish brain)
• In Vivo:
  Zebrafish male adults were acutely exposed to 0.001, 0.01 and 0.1 μg/mL pyriproxyfen for 16 h. Mitochondrial respiration of brain tissues was assessed. ROS generation was estimated using H2DCF-DA and MitoSOX. Calcium transport was monitored by Calcium Green 5 N. NO synthesis activity was estimated using DAF-FM-DA. Brain acetylcholinesterase showed an in vivo IC20 of 0.30 μmol/L pyriproxyfen, and an IC50 of 92.5 μmol/L. The inhibitory effect on zbAChE activity was competitive-like. Respiratory control of Complex I/II decreased significantly after insecticide exposure. The MitoSOX test showed that O2- generation had a pyriproxyfen dose-dependent effect. Brain tissue lost 50% of Ca2+ uptake capacity at 0.1 μg/mL pyriproxyfen. Ca2+ release showed a clear mitochondrial impairment at lower pyriproxyfen exposures.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

inhibit, Parasite, Inhibitor, Autophagy, Pyriproxyfen, S31183, S-31183, S 31183

Compound Identifiers

PubChem CID

91753