Pyridoxylamine

SKU: orb1940770

Description

Pyridoxylamine is an inhibitor of advanced glycation end production (AGEs) and lipoxidation end products (ALEs).(In Vitro):Pyridoxylamine (PM) is a member of the B6 vitamer family,and is a potent scavenger of reactive carbonyls, inhibiting the late stages of glycation reactions that lead to AGE formation.(In Vivo):In STZ diabetic rats, Pyridoxylamine inhibited the formation of CML and CEL and the cross-linking of skin collagen, ultimately inhibiting the development of nephropathy. Pyridoxamine does not appear to act as an antioxidant because it does not inhibit lipid peroxidation. However, it prevents modification of proteins by lipid peroxidation products, including inhibition of the formation of adducts of malondialdehyde and 4-hydroxynonenal on proteins in Zucker rats .

Key Properties

• CAS Number: 85-87-0
• MW: 168.19
• Purity: >98% (HPLC)
• Formula: C₈H₁₂N₂O₂
• SMILES: OCC1=C(CN)C(O)=C(C)N=C1
• Target: Endogenous Metabolite
• Solubility: In Vitro: DMSO : 16.67 mg/mL (99.11 mM)

Bioactivity

• In Vivo:
  Pyridoxylamine limits the formation of CML and CEL and cross-linking in skin collagen and, ultimately inhibits the development of nephropathy in STZ-diabetic rats. Pyridoxylamine does not appear to function as an antioxidant since it does not prevent lipid peroxidation reactions. At the same time, it does prevent protein modification by products of lipid peroxidation, including inhibiting formation of malondialdehyde and 4-hydroxynonenal adducts on protein in Zucker rats In vivo.
• In Vitro:
  Pyridoxylamine (PM), a member of the B6 vitamer family, is a potent scavenger of reactive carbonyls, inhibiting the late stages of glycation reactions that lead to AGE formation.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

pyridoxamine

Quick Database Links

Gene Symbol

Endogenous Metabolite